Topical phenytoin accelerates healing in epidermolysis bullosa simplex.
نویسندگان
چکیده
منابع مشابه
Epidermolysis Bullosa associated with pyloric stenosis: A case report
Epidermolysis bullosa are a group of hereditary skin diseases manifested as blisters on the sites of trauma to the skin. According to the level of blister development, epidermolysis bullosa are divided into the following groups: epidermolysis bullosa simplex, junctional epidermolysis bullosa and dystrophic epidermolysis bullosa. The latter two groups are associated with poorer prognosis and hig...
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The Dowling-Meara variant of epidermolysis bullosa simplex (EBS-DM) is a severe blistering disease inherited in an autosomal-dominant fashion. Here we report the generation of a mouse model that allows focal activation of a mutant keratin 14 allele in epidermal stem cells upon topical administration of an inducer, resulting in EBS phenotypes in treated areas. Using laser capture microdissection...
متن کاملEffect of Phenytoin in Wound Healing: A Review
Phenytoin (diphenlhydantion or Dilantin) is a highly effective and widely prescribed anticonvulsant agent and antiarrhythmic agent in the treatment of grand mal and psychomotor epilepsy. Phentoin was introduced into therapy in 1937 for effective convulsive disorder with a common side effect being gingival hyperplasia. In dermatology due to the stimulatory effect on the connective tissue it is u...
متن کاملEpidermolysis Bullosa: Experience from the Western Province of Saudi Arabia
Epidermolysis bullosa is a rare inherited bullous disease with unknown prevalence in most parts of the world. In Saudi Arabia the reported studies regarding epidermolysis bullosa are very limited. This paper presents the first study of epidermolysis bullosa cases from the Western province of Saudi Arabia. We studied 15 cases of inherited epidermolysis bullosa and classified the cases based on e...
متن کاملTopical diacerein for epidermolysis bullosa: a randomized controlled pilot study
Blistering in epidermolysis bullosa simplex type Dowling-Meara (EBS-DM) is associated with an inflammatory phenotype, which can be disrupted by diacerein in vitro. In this pilot study we hypothesized, that a topical formulation of diacerein 1% reduces blistering. Five patients initially applied diacerein underneath both armpits. Then, each participant received 1% diacerein-cream for one armpit,...
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ورودعنوان ژورنال:
- Dermatology
دوره 190 3 شماره
صفحات -
تاریخ انتشار 1995